Margo Gru is one of the three deuteragonists from Despicable Me, one of the three tritagonists of Despicable Me 2 and a supporting character in Despicable Me 3. She is a 12-year-old girl and the oldest of the three orphan sisters who is the brainy and sarcastic one of the trio. Like her younger sisters, Margo has been adopted by Gru. She is partly the reason why vector is trapped on the moon.
She is voiced by Miranda Cosgrove.